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Tg(LRRK2*R1441G)135Cjli
Transgene Detail
Nomenclature
Symbol: Tg(LRRK2*R1441G)135Cjli
Name: transgene insertion 135, Chenjian Li
MGI ID: MGI:3847811
Synonyms: LRRK2R1441G, TG-RP135
Transgene: Tg(LRRK2*R1441G)135Cjli  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/NTac
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(LRRK2*R1441G)135Cjli expresses 1 gene
 
Mutation detailsA human bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 188 kb BAC containing the entire human LRRK2 (leucine-rich repeat kinase 2) gene with 29 kb upstream of the LRRK2 start codon and 42 kb downstream of the LRRK2 stop codon. Bioinformatics analysis predicted that no other genes are present in the BAC. This BAC was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2 R1441G (4321C>G) mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. (J:149135)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:149135 Li Y, et al., Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci. 2009 Jun 7;12(7):826-8
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory