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Tg(SERPINA1*E342K)#Slcw
Transgene Detail
Nomenclature
Symbol: Tg(SERPINA1*E342K)#Slcw
Name: transgene insertion, Savio L C Woo
MGI ID: MGI:3847801
Synonyms: ATZ, PiZ, Tg(SERPINA1*E342K)Z1.01Slcw, Z1.01
Transgene: Tg(SERPINA1*E342K)#Slcw  Location: unknown  
Transgene
origin
Strain of Origin:  (ICR x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SERPINA1*E342K)#Slcw expresses 1 gene
 
Mutation detailsThe transgene construct contains the entire human alpha1-antitrypsin (AAT or SERPINA1) gene encoding the Z variant allele which has a Glu->Lys substitution at position 342, plus 2.0 and 2.3 kb of 5' and 3' genomic sequences, respectively. (J:149132, J:149133)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:149132 Carlson JA, et al., Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice. J Clin Invest. 1989 Apr;83(4):1183-90
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory