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Pds5aGt(RRM243)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Pds5aGt(RRM243)Byg
Name: PDS5 cohesin associated factor A; gene trap RRM243, BayGenomics
MGI ID: MGI:3847257
Synonyms: Pds5A-
Gene: Pds5a  Location: Chr5:65605719-65698236 bp, - strand  Genetic Position: Chr5, 33.76 cM, cytoband C3.3
Pds5aGt(RRM243)Byg/Pds5aGt(RRM243)Byg mice display growth retardation, abnormal skeletal patterning and cleft pallet

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  RRM243
Germline Transmission:  Earliest citation of germline transmission: J:148890
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
 
Mutation detailsThe pGT0lxf vector, containing a beta-geo cassette, inserted into intron 2 and disrupted normal gene splicing. The absence of wild-type protein expression was confirmed by western blot analysis on E18.5 kidney extracts. (J:148890)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Generation of the Pds5aGt(RRM243)Byg allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pds5a Mutation:  8 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:148890 Zhang B, et al., Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One. 2009;4(5):e5232
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory