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Ucp1m1H
Spontaneous Allele Detail
Nomenclature
Symbol: Ucp1m1H
Name: uncoupling protein 1 (mitochondrial, proton carrier); mutation 1, Harwell
MGI ID: MGI:3847238
Synonyms: TRI, UCP1 SNP
Gene: Ucp1  Location: Chr8:84016981-84025081 bp, + strand  Genetic Position: Chr8, 39.65 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Single point mutation
 
Mutation detailsThis spontaneous mutation, discovered in the C57BL/6J colony at the Medical Research Council, Harwell, UK, has been identified as a point mutation (C-to-A) in exon 5 that introduces a new acceptor splice site. It is located at position chr2:83295206 (GRCm38) and creates a new CAG splice acceptor site from CCG. This acceptor is used in splicing, removing the first 39 nucleotides of exon 5 from the mRNA and 13 amino-acids from the encoded peptide. (J:148827)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ucp1 Mutation:  33 strains or lines available
References
Original:  J:148827 Moir L, et al., TRI is an allele of Ucp1 and results in thermoregulation defects: Record for Ucp11H. MGI Direct Data Submission. 2009;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory