Stk4^tm1Kina
Targeted Allele Detail

Summary

• Symbol: Stk4^tm1Kina
• Name: serine/threonine kinase 4; targeted mutation 1, Tatsuo Kinashi
• MGI ID: MGI:3847088
• Synonyms: Mst1^f
• Gene: Stk4 Location: Chr2:163916033-163997444 bp, + strand Genetic Position: Chr2, 84.6 cM, cytoband H3
• Alliance: Stk4^tm1Kina page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148791
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into a Ssp I restriction site 1.1 kb upstream of exon 1, and a floxed neomycin cassette was placed 1 kb downstream of exon 1. ES cells with the targeted locus were transiently infected with a cre-expressing adenovirus to generate exon 1 flanked with loxP sites. Expression of the locus was not affected as determined by immunoblot analysis of spleen, thymus, brain and lung tissues. (J:148791)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk4 Mutation: 72 strains or lines available

References

• Original: J:148791 Katagiri K, et al., Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J. 2009 May 6;28(9):1319-31
• All: 10 reference(s)