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Stk4tm1Kina
Targeted Allele Detail
Nomenclature
Symbol: Stk4tm1Kina
Name: serine/threonine kinase 4; targeted mutation 1, Tatsuo Kinashi
MGI ID: MGI:3847088
Synonyms: Mst1f
Gene: Stk4  Location: Chr2:164074113-164155524 bp, + strand  Genetic Position: Chr2, 84.6 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148791
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into a Ssp I restriction site 1.1 kb upstream of exon 1, and a floxed neomycin cassette was placed 1 kb downstream of exon 1. ES cells with the targeted locus were transiently infected with a cre-expressing adenovirus to generate exon 1 flanked with loxP sites. Expression of the locus was not affected as determined by immunoblot analysis of spleen, thymus, brain and lung tissues. (J:148791)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk4 Mutation:  18 strains or lines available
References
Original:  J:148791 Katagiri K, et al., Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J. 2009 May 6;28(9):1319-31
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory