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Sgk1tm1.2Palm
Targeted Allele Detail
Nomenclature
Symbol: Sgk1tm1.2Palm
Name: serum/glucocorticoid regulated kinase 1; targeted mutation 1.2, Lawrence G Palmer
MGI ID: MGI:3846797
Gene: Sgk1  Location: Chr10:21882184-21999903 bp, + strand  Genetic Position: Chr10, 9.83 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148648
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted into the BsaHI site in intron 1, and a loxP site and a FRT-flanked neomycin cassette was inserted into the XcmI site in intron 6. Mice carrying this allele were crossed with cre deleter mice to remove exons 2-6. Gene inactivation was confirmed by RT-PCR analysis of homozygous kidney extracts. (J:148648)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgk1 Mutation:  129 strains or lines available
References
Original:  J:148648 Fejes-Toth G, et al., Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1298-305
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory