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Ptgs2tm3Fun
Targeted Allele Detail
Nomenclature
Symbol: Ptgs2tm3Fun
Name: prostaglandin-endoperoxide synthase 2; targeted mutation 3, Colin D Funk
MGI ID: MGI:3846762
Synonyms: COX-2Neo
Gene: Ptgs2  Location: Chr1:150100031-150108227 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148699
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted into intron 9 via homologous recombination. Western blot analysis confirmed decreased protein expression in unstimulated and stimulated macrophages and endothelial cells from homozygous mice. (J:148699)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:  32 strains or lines available
References
Original:  J:148699 Seta F, et al., Renal and cardiovascular characterization of COX-2 knockdown mice. Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1751-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory