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Targeted Allele Detail
Symbol: Fat4tm1.1Hmc
Name: FAT atypical cadherin 4; targeted mutation 1.1, Helen McNeill
MGI ID: MGI:3846573
Synonyms: Fat4-, Fat42E11 deltaflox
Gene: Fat4  Location: Chr3:38886940-39011985 bp, + strand  Genetic Position: Chr3, 18.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:138247
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 3 and a loxP site and frt flanked PGK-neo cassette were inserted downstream of exon 3 via homologous recombination. Two mutant ES cell lines acquired the two loxP insertion in the targeted gene. This allele is derived from line 2E11 in which targeting occured as expected. Subsequent Cre mediated recombination removed exon 3. (J:138247)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fat4 Mutation:  109 strains or lines available

ES cell line = 129/1, a subline of GK129.
Original:  J:138247 Saburi S, et al., Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet. 2008 Aug;40(8):1010-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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