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Col14a1tm1Debi
Targeted Allele Detail
Nomenclature
Symbol: Col14a1tm1Debi
Name: collagen, type XIV, alpha 1; targeted mutation 1, David E Birk
MGI ID: MGI:3846440
Gene: Col14a1  Location: Chr15:55307750-55520803 bp, + strand  Genetic Position: Chr15, 21.96 cM, cytoband D
Altered fibroblast and fiber organization in P4 tendons from Col14a1tm1Debi/Col14a1tm1Debi mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148619
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA nonsense mutation was generated by inserting a stop codon followed by a neo-TK cassette into exon 4. Immunoblot analysis confirmed the absence of protein expression in the skin of homozygous mice at P12 and P60 (J:148619)
Creation of the Col14a1tm1Debi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col14a1 Mutation:  2 strains or lines available
References
Original:  J:148619 Ansorge HL, et al., Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE. J Biol Chem. 2009 Mar 27;284(13):8427-38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory