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Cisd2tm1Tfts
Targeted Allele Detail
Nomenclature
Symbol: Cisd2tm1Tfts
Name: CDGSH iron sulfur domain 2; targeted mutation 1, Ting-Fen Tsai
MGI ID: MGI:3846404
Gene: Cisd2  Location: Chr3:135406412-135423925 bp, - strand  Genetic Position: Chr3, 62.55 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148467
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Duplication, Insertion
 
Mutation detailsThe genomic sequence extending from the 3' end of intron 1 through the 5' end of exon 3 was replaced with the missing portion of intron 1 through the 5' end of exon 3 following by a puromycin resistance cassette, loxP site, 3'Hprt mini-gene, and a duplication of the 3' end of intron 1 through the 5' end of exon 3. The absence of transcript expression was confirmed by northern blot analysis on brain extracts. (J:148467)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cisd2 Mutation:  23 strains or lines available
References
Original:  J:148467 Chen YF, et al., Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. Genes Dev. 2009 May 15;23(10):1183-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory