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Nelfbtm1.1Roli
Targeted Allele Detail
Nomenclature
Symbol: Nelfbtm1.1Roli
Name: negative elongation factor complex member B; targeted mutation 1.1, Rong Li
MGI ID: MGI:3846130
Synonyms: Cobra1fl
Gene: Nelfb  Location: Chr2:25199712-25211489 bp, - strand  Genetic Position: Chr2, 17.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148508
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA frt- and neo-flanked neo cassette was inserted upstream of exon 1, and an additional loxP site was inserted downstream of exon 4. Germ line, flp mediated recombination removed the neo cassette leaving exons 1 through 4 floxed. (J:148508)
Generation of the Nelfbtm1.1Roli and Nelfbtm1.2Roli alleles
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nelfb Mutation:  4 strains or lines available
References
Original:  J:148508 Amleh A, et al., Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS One. 2009;4(4):e5034
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory