Plek^tm1Csab
Targeted Allele Detail

Summary

• Symbol: Plek^tm1Csab
• Name: pleckstrin; targeted mutation 1, Charles S Abrams
• MGI ID: MGI:3845059
• Gene: Plek Location: Chr11:16921206-16958718 bp, - strand Genetic Position: Chr11, 9.41 cM
• Alliance: Plek^tm1Csab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148429
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with an HPRT gene via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in platelets from homozygous mice. (J:148429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plek Mutation: 30 strains or lines available

References

• Original: J:148429 Lian L, et al., Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood. 2009 Apr 9;113(15):3577-84
• All: 1 reference(s)