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Gt(ROSA)26Sortm2(Nfatc2*)Rao
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2(Nfatc2*)Rao
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Anjana Rao
MGI ID: MGI:3844635
Synonyms: R26STOPflox-AV-NFAT1
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2(Nfatc2*)Rao page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148341
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(Nfatc2*)Rao expresses 1 gene
 
Mutation detailsA construct consisting of a splice acceptor site, floxed neo-stop cassette, hyperactivatable Nfatc2 gene, and an frt flanked IRES-GFP cassette was inserted into intron 1 via homologous recombination. The hyperactivatable Nfatc2 gene contains mutations in the calcineurin docking site resulting in higher affinity for ligand and mutations in the CK1 docking site resulting in lower affinity for the ligand. The mutant protein sequences for the calcineurin site and the CK1 site are HPVIVITGP and ASILA, respectively. (J:148341)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:148341 Muller MR, et al., Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7034-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory