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Hoxc4tm2.1Mrc
Targeted Allele Detail
Nomenclature
Symbol: Hoxc4tm2.1Mrc
Name: homeobox C4; targeted mutation 2.1, Mario R Capecchi
MGI ID: MGI:3844593
Gene: Hoxc4  Location: Chr15:103018934-103036852 bp, + strand  Genetic Position: Chr15, 58.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148278
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted into exon 2 into the homeodomain. Germ line, cre mediated recombination removed the neo cassette. Expression of Hoxc5 and Hoxc6 is unaltered unlike in other knock-out alleles. (J:148278)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxc4 Mutation:  2 strains or lines available
References
Original:  J:148278 Park SR, et al., HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat Immunol. 2009 May;10(5):540-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory