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Htr6tm1Tct
Targeted Allele Detail
Nomenclature
Symbol: Htr6tm1Tct
Name: 5-hydroxytryptamine (serotonin) receptor 6; targeted mutation 1, Laurence H Tercott
MGI ID: MGI:3844587
Gene: Htr6  Location: Chr4:139061108-139075570 bp, - strand  Genetic Position: Chr4, 70.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148381
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 300 bp fragment of exon 1 was replaced with a pgk-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of wild-type transcript in brains from homozygous mice. (J:148381)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr6 Mutation:  11 strains or lines available
References
Original:  J:148381 Bonasera SJ, et al., A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology. 2006 Aug;31(8):1801-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory