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Targeted Allele Detail
Symbol: Agr2tm1.2Erle
Name: anterior gradient 2; targeted mutation 1.2, David J Erle
MGI ID: MGI:3844570
Gene: Agr2  Location: Chr12:35992925-36004081 bp, + strand  Genetic Position: Chr12, 16.18 cM
Agr2tm1.2Erle/Agr2tm1.2Erle mice are devoid of intestinal mucus

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:148339
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3 were floxed by insertion of a loxP site upstream of exon 2 and the addition of a FRT-neo-loxP-FRT-loxP cassette downstream of exon 3. The neo cassette was subsequently removed from correctly targeted ES cells by transient expression of FLPe recombinase. Mice carrying the floxed allele were crossed with transgenic mice that express cre recombinase in the germline to create a null allele. Gene inactivation was confirmed by RT-PCR analysis on intestinal extracts. (J:148339)
Generation of the Agr2tm1.2Erle allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agr2 Mutation:  14 strains or lines available
Original:  J:148339 Park SW, et al., The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6950-5
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory