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Tg(CAG-PKD2)#Hwl
Transgene Detail
Nomenclature
Symbol: Tg(CAG-PKD2)#Hwl
Name: transgene insertion, Han-Woong Lee
MGI ID: MGI:3844550
Transgene: Tg(CAG-PKD2)#Hwl  Location: unknown  
Cystic kidneys in Tg(CAG-PKD2)#Hwl/? mice

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-PKD2)#Hwl expresses 1 gene
 
Mutation detailsThe chicken beta actin promoter and cytomegalovirus immediate early enhancer (pCAGGS) drive expression of a human PKD2 cDNA. Four lines (C, D, E, F) were generated all containing multiple copies of the transgene. Semi quantitative RT-PCR and western blot analysis confirmed expression of the transgene in the kidneys. This record is for data pooled from multiple lines. (J:148377)
Schematic of the Tg(CAG-PKD2)#Hwl transgene
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:148377 Park EY, et al., Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice. J Biol Chem. 2009 Mar 13;284(11):7214-22
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory