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Targeted Allele Detail
Symbol: Rsad2tm1Kchc
Name: radical S-adenosyl methionine domain containing 2; targeted mutation 1, Keh-Chuang Chin
MGI ID: MGI:3844545
Synonyms: viperin-
Gene: Rsad2  Location: Chr12:26442753-26456452 bp, - strand  Genetic Position: Chr12, 9.69 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:148305
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 and 2 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on splenic CD4+ T cell extracts. The absence of protein expression was confirmed by immunohistochemistry on the spleen and stimulated CD4+ T cells. (J:148305)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rsad2 Mutation:  15 strains or lines available
Original:  J:148305 Qiu LQ, et al., Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood. 2009 Apr 9;113(15):3520-9
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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