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Rsad2tm1Kchc
Targeted Allele Detail
Nomenclature
Symbol: Rsad2tm1Kchc
Name: radical S-adenosyl methionine domain containing 2; targeted mutation 1, Keh-Chuang Chin
MGI ID: MGI:3844545
Synonyms: viperin-
Gene: Rsad2  Location: Chr12:26442753-26456452 bp, - strand  Genetic Position: Chr12, 9.69 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148305
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and 2 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on splenic CD4+ T cell extracts. The absence of protein expression was confirmed by immunohistochemistry on the spleen and stimulated CD4+ T cells. (J:148305)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rsad2 Mutation:  10 strains or lines available
References
Original:  J:148305 Qiu LQ, et al., Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood. 2009 Apr 9;113(15):3520-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory