Rsad2^tm1Kchc
Targeted Allele Detail

Summary

• Symbol: Rsad2^tm1Kchc
• Name: radical S-adenosyl methionine domain containing 2; targeted mutation 1, Keh-Chuang Chin
• MGI ID: MGI:3844545
• Synonyms: viperin^-
• Gene: Rsad2 Location: Chr12:26492745-26506451 bp, - strand Genetic Position: Chr12, 9.69 cM, cytoband A3
• Alliance: Rsad2^tm1Kchc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148305
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and 2 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on splenic CD4+ T cell extracts. The absence of protein expression was confirmed by immunohistochemistry on the spleen and stimulated CD4+ T cells. (J:148305)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rsad2 Mutation: 26 strains or lines available

References

• Original: J:148305 Qiu LQ, et al., Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood. 2009 Apr 9;113(15):3520-9
• All: 8 reference(s)