Hpse^tm1Jpli
Targeted Allele Detail

Summary

• Symbol: Hpse^tm1Jpli
• Name: heparanase; targeted mutation 1, Jin-Ping Li
• MGI ID: MGI:3844469
• Synonyms: Hpa-ko, Hpse^-
• Gene: Hpse Location: Chr5:100827350-100867582 bp, - strand Genetic Position: Chr5, 48.51 cM
• Alliance: Hpse^tm1Jpli page

Mammary glands of virgin Hpse^tm1Jpli/Hpse^tm1Jpli females show increased branching of the ducts and precocious alveolar structures

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148281
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on spleen and lung extracts. (J:148281)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Hpse Mutation: 37 strains or lines available

References

• Original: J:148281 Zcharia E, et al., Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One. 2009;4(4):e5181
• All: 24 reference(s)