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Tg(Thy1-Nlgn2)6Hnes
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-Nlgn2)6Hnes
Name: transgene insertion 6, Rochelle Hines
MGI ID: MGI:3844455
Synonyms: TgNL2.6
Transgene: Tg(Thy1-Nlgn2)6Hnes  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-Nlgn2)6Hnes expresses 1 gene
 
Mutation detailsThe TgNL2 transgene was designed with a modified regulatory region of the "murine thy1.2 gene" (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns) upstream of a hemagglutinin-tagged rat neuroligin 2 (Nlgn2 or NL2) cDNA. Transgenic founders were bred with C57BL/6 and mice from founder line 6 (TgNL2.6) were found to have an approximately 1.6-fold increase in NL2 expression and moderate phenotype severity, (J:137376)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:137376 Hines RM, et al., Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci. 2008 Jun 11;28(24):6055-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory