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Targeted Allele Detail
Symbol: Cpt1ctm1Dhwu
Name: carnitine palmitoyltransferase 1c; targeted mutation 1, Donghai Wu
MGI ID: MGI:3844092
Gene: Cpt1c  Location: Chr7:44959373-44974851 bp, - strand  Genetic Position: Chr7, 29.07 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:148205
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.3 kb fragment including exon 3 was replaced with a pgk-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in the brains of homozygous mice. (J:148205)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpt1c Mutation:  25 strains or lines available
Original:  J:148205 Gao XF, et al., Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. Diabetologia. 2009 May;52(5):912-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory