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Targeted Allele Detail
Symbol: Prss16tm1Mal
Name: protease, serine 16 (thymus); targeted mutation 1, Bernard Malissen
MGI ID: MGI:3843929
Synonyms: TSSP-, Tsspo
Gene: Prss16  Location: Chr13:22002176-22009741 bp, - strand  Genetic Position: Chr13, 8.12 cM, cytoband A3-A5
Germline Transmission:  Earliest citation of germline transmission: J:148034
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 8-12 of the locus were replaced by a self-excising floxed neomycin and cre recombinase expression cassette. Genomic PCR on homozygotes confirmed deletion of both the exons and the selection cassette. Northern and Western blots on homozygote thymi extracts confirmed gene inactivation. (J:148034)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Prss16 Mutation:  7 strains or lines available
Original:  J:148034 Gommeaux J, et al., Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes. Eur J Immunol. 2009 Apr;39(4):956-64
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory