Lat^tm1.2Wz
Targeted Allele Detail

Summary

• Symbol: Lat^tm1.2Wz
• Name: linker for activation of T cells; targeted mutation 1.2, Weiguo Zhang
• MGI ID: MGI:3843464
• Synonyms: LAT^d
• Gene: Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
• Alliance: Lat^tm1.2Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147946
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exons 7 through 11. Expression of the EGFP is detected as early as DN1 stage. (J:147946)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat Mutation: 9 strains or lines available

References

• Original: J:147946 Shen S, et al., The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol. 2009 May 1;182(9):5596-604
• All: 1 reference(s)