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Targeted Allele Detail
Symbol: Tnfrsf4tm2(cre)Nik
Name: tumor necrosis factor receptor superfamily, member 4; targeted mutation 2, Nigel Killeen
MGI ID: MGI:3843034
Synonyms: Ox40-Cre
Gene: Tnfrsf4  Location: Chr4:156013843-156016612 bp, + strand  Genetic Position: Chr4, 87.68 cM
Germline Transmission:  Earliest citation of germline transmission: J:147746
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Mutation details1.7 kb of the locus containing exons 1, 2 and part of 3 was fused to an IRES-cre construct followed by a FRT-flanked neomycin selection element. After targeted recombination, the neomycin element was removed by crossing founder mice with FLPe transgenic mice. Insertion of the cre expression construct disrupted the endogenous locus, creating a null allele. Cre expression was detected in male but not female germline cells, in memory and regulatory CD4+ T cells, and in some CD8+ and naive CD4+ T cells. (J:147746)
 Tissue activity of this recombinase allele
Driver: Tnfrsf4     Summary of all recombinase alleles driven by Tnfrsf4.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf4 Mutation:  19 strains or lines available
Original:  J:147746 Klinger M, et al., Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol. 2009 Apr 15;182(8):4581-9
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory