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Zc3h12atm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Zc3h12atm1Aki
Name: zinc finger CCCH type containing 12A; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3843029
Synonyms: Reg1-
Gene: Zc3h12a  Location: Chr4:125118423-125127840 bp, - strand  Genetic Position: Chr4, 58.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147868
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 5 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on LPS-stimulated macrophage extracts. (J:147868)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zc3h12a Mutation:  17 strains or lines available
References
Original:  J:147868 Matsushita K, et al., Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 2009 Apr 30;458(7242):1185-90
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory