Esr1^tm1.2Awo
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.2Awo
• Name: estrogen receptor 1 (alpha); targeted mutation 1.2, Andrew Wolfe
• MGI ID: MGI:3842664
• Synonyms: ERalpha^lox
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.2Awo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152925
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The self-excising neo cassette removed itself leaving exon 3 floxed. (J:152925)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 67 strains or lines available

References

• Original: J:152925 Singh SP, et al., Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1). Biol Reprod. 2009 Sep;81(3):488-96
• All: 8 reference(s)