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Meg3tm1Kono
Targeted Allele Detail
Nomenclature
Symbol: Meg3tm1Kono
Name: maternally expressed 3; targeted mutation 1, Tomohiro Kono
MGI ID: MGI:3842511
Gene: Meg3  Location: Chr12:109541001-109571726 bp, + strand  Genetic Position: Chr12, 60.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147577
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 10 kb region including exons 1 through 5 and all of the upstream differentially methylated region was replaced with a neo cassette via homologous recombination. (J:147577)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 294 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Meg3 Mutation:  1 strain or line available
References
Original:  J:147577 Takahashi N, et al., Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice. Hum Mol Genet. 2009 May 15;18(10):1879-88
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory