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Targeted Allele Detail
Symbol: Atf2tm1Sis
Name: activating transcription factor 2; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:3842320
Synonyms: ATF-2o
Gene: Atf2  Location: Chr2:73816509-73892639 bp, - strand  Genetic Position: Chr2, 43.86 cM
Respiration defects of the Atf2tm1Glm/Atf2tm1Glm mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:55657
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance gene was inserted into the exon (amino acids 327-395) that encodes the DNA-binding domain consisting of the basic amino acid region between amino acids 378 and 379. Western blot analysis confirmed absence of protein. (J:55657)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Atf2 Mutation:  46 strains or lines available
Original:  J:55657 Maekawa T, et al., Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. J Biol Chem. 1999 Jun 18;274(25):17813-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory