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Cyp11b1tm1Chjk
Targeted Allele Detail
Nomenclature
Symbol: Cyp11b1tm1Chjk
Name: cytochrome P450, family 11, subfamily b, polypeptide 1; targeted mutation 1, Christopher J Kenyon
MGI ID: MGI:3841929
Gene: Cyp11b1  Location: Chr15:74834892-74841643 bp, - strand  Genetic Position: Chr15, 34.29 cM
Cyp11b1tm1Chjk/Cyp11b1tm1Chjk mice display adrenal hypertrophy

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147610
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 7 were replaced with an IRES-ECFP and neo cassette. Immunohistochemistry confirmed the absence of protein expression in the zona fasciculata. (J:147610)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp11b1 Mutation:  3 strains or lines available
References
Original:  J:147610 Mullins LJ, et al., Cyp11b1 null mouse, a model of congenital adrenal hyperplasia. J Biol Chem. 2009 Feb 6;284(6):3925-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory