Tg(SFTPC-cre)11Yo
Transgene Detail

Summary

• Symbol: Tg(SFTPC-cre)11Yo
• Name: transgene insertion 11, Yuichi Oike
• MGI ID: MGI:3841690
• Synonyms: SPC-Cre, SPCp-Cre, SPC-p Cre Tg
• Transgene: Tg(SFTPC-cre)11Yo Location: unknown
• Alliance: Tg(SFTPC-cre)11Yo page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(SFTPC-cre)11Yo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  SFTPC (6440)

  Sftpc

  (MGI:109517)

• Mutation details: The transgenic construct contains the 4.1 kb human pro-surfactant protein C promoter (from an RPCl-11 human BAC clone) driving the Cre recombinase sequence. This construct was injected into the pronuclei of C57BL/6 blastocysts. Five founders were generated, and from crosses to transgenic reporter mice, lines 11 and 14 exhibited reporter expression in the lungs. Both lines contain a single transgene copy and were propagated for further study. (J:147388)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	SFTPC (human) Summary of all recombinase alleles driven by SFTPC. Comparative matrix view of recombinase activities Alliance human SFTPC gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:147388 Hato T, et al., Angiopoietins contribute to lung development by regulating pulmonary vascular network formation. Biochem Biophys Res Commun. 2009 Apr 3;381(2):218-23
• All: 4 reference(s)