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Tg(Myh6/tetO-PRKAG2*N488I)1Chib
Transgene Detail
Nomenclature
Symbol: Tg(Myh6/tetO-PRKAG2*N488I)1Chib
Name: transgene insertion 1, Charles I Berul
MGI ID: MGI:3841177
Transgene: Tg(Myh6/tetO-PRKAG2*N488I)1Chib  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6/tetO-PRKAG2*N488I)1Chib expresses 1 gene
 
Mutation detailsA fusion promoter with tetO was used to drive repressible, cardiac expression of the human gene with an T to A substitution at position 1553 that results in the amino acid substitution of asparagine with isoleucine at position 488 (N488I). Thirteen lines were created with 2 exhibiting robust expression and phenotype. No line numbers were given. (J:145090)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:145090 Wolf CM, et al., Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 2008 Jan 15;117(2):144-54
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory