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Targeted Allele Detail
Symbol: Foxo1tm1Flv
Name: forkhead box O1; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3840910
Synonyms: Foxo1flox
Gene: Foxo1  Location: Chr3:52268337-52350109 bp, + strand  Genetic Position: Chr3, 23.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:147057
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted into the XbaI restriction site upstream of exon 1 and a frt-flanked neoymycin cassette with a 3' loxP site was inserted downstream of exon 1. Mice were crossed with transgenic Flipase to remove the neomycin cassette, leaving exon 1 floxed. Protein expression was unaffected as determined by immunoblot analysis of homozygote lymphocyte extracts. (J:147057)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxo1 Mutation:  6 strains or lines available
Original:  J:147057 Ouyang W, et al., An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity. 2009 Mar;30(3):358-71
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory