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Targeted Allele Detail
Symbol: Oprm1tm1Yxp
Name: opioid receptor, mu 1; targeted mutation 1, Ying-Xian Pan
MGI ID: MGI:3840671
Gene: Oprm1  Location: Chr10:6758506-7038198 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:147079
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 11 and part of the adjacent intron, which are located about 30 kb upstream of exon 1, were replaced with an IRES/tau/lacZ-loxP/tk-neo/loxP cassette via homologous recombination. RT-PCR analysis confirmed the absence of transcripts that include exon 11 and indicated about a 25% decrease in overall Oprm1 RNA expression. Receptor binding assays indicated a 21% decrease in binding site density. (J:147079)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  20 strains or lines available
Original:  J:147079 Pan YX, et al., Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4917-22
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory