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Lats1tm1Noj
Targeted Allele Detail
Summary
Symbol: Lats1tm1Noj
Name: large tumor suppressor; targeted mutation 1, Hiroshi Nojima
MGI ID: MGI:3840659
Synonyms: Lats1deltaN
Gene: Lats1  Location: Chr10:7556978-7592224 bp, + strand  Genetic Position: Chr10, 2.29 cM, cytoband A1
Alliance: Lats1tm1Noj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147050
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first coding exon, encoding exons 1 through 117, was replaced with a pgk-neomycin resistance cassette via homologous recombination. Western blot analysis confirmed the expression of the truncated protein. (J:147050)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lats1 Mutation:  48 strains or lines available
References
Original:  J:147050 Nishioka N, et al., The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009 Mar;16(3):398-410
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory