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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo
Name: gene trap ROSA 26, Philippe Soriano; Targeted mutation 1, Darren Moore
MGI ID: MGI:3840598
Synonyms: ROSA26-Syn-A53T, ROSA26-SynA53TTg
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:147332
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm1(SNCA*A53T)Djmo expresses 1 gene
Mutation detailsA targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a human alpha-synuclein cDNA bearing a familial Parkinson's disease-linked A53T missense mutation (SYNA53T), and a bovine polyadenylation signal. (J:147332, J:150777)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  497 strains or lines available
Original reference states that 129/SvJ-derived embryonic stem cells were used.
Original:  J:147332 Moore D, Generation of a conditional knockin allele expressing the human alpha-synuclein sequence with the A53T mutation. MGI Direct Data Submission. 2009;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory