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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm2(SNCA*119)Djmo
Name: gene trap ROSA 26, Philippe Soriano; Targeted mutation 2, Darren Moore
MGI ID: MGI:3840596
Synonyms: ROSA26-a-synuclein C-terminal truncation variant (Syn119), ROSA26-Syn119, ROSA26-SynCT119Tg
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:147331
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm2(SNCA*119)Djmo expresses 1 gene
Mutation detailsA targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a cDNA encoding the 119 amino acid C-terminal truncation of human alpha-synuclein associated with familial Parkinson's disease (Syn119 or SynCT119; encoding amino acids 1-119 of the full length protein), and a bovine polyadenylation signal. (J:147331, J:150777)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  291 strains or lines available
Authors state that 129/SvJ-derived embryonic stem cells were used.

Original:  J:147331 Moore D, Generation of a conditional knockin allele expresing a truncated human alpha-synuclein (SNCA). MGI Direct Data Submission. 2009;
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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