Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Darren Moore
• MGI ID: MGI:3840596
• Synonyms: ROSA26-a-synuclein C-terminal truncation variant (Syn119), ROSA26-Syn119, ROSA26-SynCT119^Tg
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: A targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a cDNA encoding the 119 amino acid C-terminal truncation of human alpha-synuclein associated with familial Parkinson's disease (Syn119 or SynCT119; encoding amino acids 1-119 of the full length protein), and a bovine polyadenylation signal. (J:147331, J:150777)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

Notes

The original refernece states that 129/SvJ-derived embryonic stem cells were used.

References

• Original: J:147331 Moore D, Generation of a conditional knockin allele expresing a truncated human alpha-synuclein (SNCA). MGI Direct Data Submission. 2009
• All: 2 reference(s)