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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm2(SNCA*119)Djmo
Name: gene trap ROSA 26, Philippe Soriano; Targeted mutation 2, Darren Moore
MGI ID: MGI:3840596
Synonyms: ROSA26-a-synuclein C-terminal truncation variant (Syn119), ROSA26-Syn119, ROSA26-SynCT119Tg
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:147331
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm2(SNCA*119)Djmo expresses 1 gene
Mutation detailsA targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a cDNA encoding the 119 amino acid C-terminal truncation of human alpha-synuclein associated with familial Parkinson's disease (Syn119 or SynCT119; encoding amino acids 1-119 of the full length protein), and a bovine polyadenylation signal. (J:147331, J:150777)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  497 strains or lines available
The original refernece states that 129/SvJ-derived embryonic stem cells were used.
Original:  J:147331 Moore D, Generation of a conditional knockin allele expresing a truncated human alpha-synuclein (SNCA). MGI Direct Data Submission. 2009;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory