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Targeted Allele Detail
Symbol: Cyp1a2/Cyp1a1tm1.1Bra
Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 1.1, Christopher A Bradfield
MGI ID: MGI:3840320
Synonyms: Cyp1a1/Cyp1a2tm1.1Bra, DREC-
Gene: Cyp1a2  Location: Chr9:57676937-57683655 bp, - strand  Genetic Position: Chr9, 31.3 cM
Increased liver inflammation and decreased hydropic degeneration in Cyp1a2/Cyp1a1tm1.1Bra/Cyp1a2/Cyp1a1tm1.1Bra mice in response to dioxin-induced toxicity

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:147150
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsAn frt flanked neo cassette followed by a loxP site were inserted upstream and a second loxP site was inserted downstream of a cluster of 7 dioxin responsive elements (DRE). These DREs regulate expression of both Cyp1a1 and Cyp1a2. The neo cassette and DRE cluster were then removed by Flp and Cre mediated recombination respectively. (J:147150)
Generation of the Cyp1a2/Cyp1a1tm1.1Bra allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp1a2 Mutation:  20 strains or lines available
Original:  J:147150 Nukaya M, et al., The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4923-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory