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Targeted Allele Detail
Symbol: Muttm1Cpv
Name: methylmalonyl-Coenzyme A mutase; targeted mutation 1, Charles P Venditti
MGI ID: MGI:3840300
Gene: Mut  Location: Chr17:40934685-40961989 bp, + strand  Genetic Position: Chr17, 19.55 cM, cytoband C-D
Enlarged mitochondria with whorl-like cristae in Muttm1Cpv/Muttm1Cpv Tg(Alb-Mut)#Cpv/0 mice fed a high-protein diet

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:147338
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was floxed and exon 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:147338)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mut Mutation:  1 strain or line available
Original:  J:147338 Chandler RJ, et al., Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle. BMC Med Genet. 2007;8:64
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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