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Targeted Allele Detail
Symbol: Ccn2tm1Mga
Name: cellular communication network factor 2; targeted mutation 1, Maureen Gannon
MGI ID: MGI:3840270
Synonyms: CTGFlacZ
Gene: Ccn2  Location: Chr10:24595442-24598683 bp, + strand  Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
Germline Transmission:  Earliest citation of germline transmission: J:145696
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 3, 4 and a part of exon 5 coding for von Willebrand factor type C domain with a transmembrane domain-lacZ/neo cassette via homologous recombination. The neo selection minigene was flanked with LoxP sites. Resulting allele produces a Ctgf N terminus/beta-gal fusion protein. (J:145696, J:200671)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccn2 Mutation:  14 strains or lines available
Original:  J:145696 Crawford LA, et al., Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis. Mol Endocrinol. 2009 Mar;23(3):324-36
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory