Kdm3a^tm1.1Yzha
Targeted Allele Detail

Summary

• Symbol: Kdm3a^tm1.1Yzha
• Name: lysine (K)-specific demethylase 3A; targeted mutation 1.1, Yi Zhang
• MGI ID: MGI:3840232
• Synonyms: Jhdm2a^1loxP, Kdm3a^deltaJC
• Gene: Kdm3a Location: Chr6:71565954-71609963 bp, - strand Genetic Position: Chr6, 32.18 cM
• Alliance: Kdm3a^tm1.1Yzha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147295
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 22 through 24 were removed by germ line, cre mediated recombination removing the catalytic jumonji C domain. The absence of protein expression was confirmed by western blot analysis on skeletal muscle extracts. (J:147295)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm3a Mutation: 79 strains or lines available

References

• Original: J:147295 Tateishi K, et al., Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature. 2009 Apr 9;458(7239):757-61
• All: 6 reference(s)