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Kdm3atm1.1Yzha
Targeted Allele Detail
Nomenclature
Symbol: Kdm3atm1.1Yzha
Name: lysine (K)-specific demethylase 3A; targeted mutation 1.1, Yi Zhang
MGI ID: MGI:3840232
Synonyms: Jhdm2a1loxP
Gene: Kdm3a  Location: Chr6:71588972-71632990 bp, - strand  Genetic Position: Chr6, 32.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147295
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 22 through 24 were removed by germ line, cre mediated recombination removing the catalytic jumonji C domain. The absence of protein expression was confirmed by western blot analysis on skeletal muscle extracts. (J:147295)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdm3a Mutation:  57 strains or lines available
References
Original:  J:147295 Tateishi K, et al., Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature. 2009 Apr 9;458(7239):757-61
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory