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Cd63tm1Psa
Targeted Allele Detail
Nomenclature
Symbol: Cd63tm1Psa
Name: CD63 antigen; targeted mutation 1, Paul Saftig
MGI ID: MGI:3840228
Synonyms: CD63-
Gene: Cd63  Location: Chr10:128908919-128912822 bp, + strand  Genetic Position: Chr10, 77.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145741
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of neo expression cassette in the third codon of exon 2. Northern blotting and RT-PCR demonstrated a complete absence of Cd63 RNA in homozygous mutant mice. (J:145741)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd63 Mutation:  13 strains or lines available
References
Original:  J:145741 Schroder J, et al., Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. Mol Cell Biol. 2009 Feb;29(4):1083-94
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory