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Gt(ROSA)26Sortm1.2(CAG-EGFP)Glh
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1.2(CAG-EGFP)Glh
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.2, David J Goldhamer
MGI ID: MGI:3840213
Synonyms: R26NG
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1.2(CAG-EGFP)Glh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147304
Parent Cell Line:  D1 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA vector containing a CAG promoter driving expression of a floxed neo/STOP cassette, frt flanked lacZ gene with 3 polyadenylation sequences (secondary STOP cassette), and an EGFP gene was inserted into the locus. Germ line, flp mediated recombination removes the lacZ/STOP cassette leaving the neo/STOP cassette intact. Cre mediated recombination is necessary to achieve EGFP expression. (J:147304)
Generation of Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh, Gt(ROSA)26Sortm1.1(CAG-lacZ,-EGFP)Glh, Gt(ROSA)26Sortm1.2(CAG-EGFP)Glh, and Gt(ROSA)26Sortm1.3(CAG-EGFP)Glh alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:147304 Yamamoto M, et al., A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis. Genesis. 2009 Feb;47(2):107-14
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory