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Hdlq55129S1/SvImJ
QTL Variant Detail
Nomenclature
QTL variant: Hdlq55129S1/SvImJ
Name: HDL QTL 55; 129S1/SvImJ
MGI ID: MGI:3839989
QTL: Hdlq55  Location: unknown  Genetic Position: Chr14, Syntenic
Variant
origin
Strain of Specimen:  129S1/SvImJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased plasma HDL concentration on an atherogenic diet compared to C57BL/6J. (J:144089)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes
Hdlq55 displays suggestive linkage to plasma HDL concentration on an atherogenic diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

A novel locus named Hdlq55 (HDL QTL 55) was identified at 100 Mb (47 cM) on mouse Chromosome 14 near rs6179144 with suggestive association to plasma HDL concentration on an atherogenic diet (LOD=2.9). 129S1/SvImJ-derived alleles at Hdlq55 confer increased plasma HDL concentration on an atherogenic diet. The 95% confidence interval for Hdlq55 spans 94 Mb (44.5 cM) to 117 Mb (54 cM).

References
Original:  J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory