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Trp53bp2tm1Cdlo
Targeted Allele Detail
Nomenclature
Symbol: Trp53bp2tm1Cdlo
Name: transformation related protein 53 binding protein 2; targeted mutation 1, Charles D Lopez
MGI ID: MGI:3839864
Synonyms: ASPP2-
Gene: Trp53bp2  Location: Chr1:182409172-182462432 bp, + strand  Genetic Position: Chr1, 84.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146764
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 10 - 17 were replaced with a floxed neo cassette via homologous recombination. Western blot analysis indicates about a 2-fold reduction in protein expression in MEFs, thymus and liver from heterozygous mice. (J:146764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53bp2 Mutation:  5 strains or lines available
References
Original:  J:146764 Kampa KM, et al., Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4390-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory