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QTL Variant Detail
QTL variant: Hdlq60129S1/SvImJ
Name: HDL QTL 60; 129S1/SvImJ
MGI ID: MGI:3839811
QTL: Hdlq60  Location: unknown  Genetic Position: ChrX, Syntenic
Strain of Specimen:  129S1/SvImJ
Allele Type:    QTL
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Hdlq60 interacts with Hdlq15 on chromosome 1.

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

A novel locus named Hdlq60 (HDL QTL 60) on mouse chromosome X was detected via interaction with Hdlq15 on chromosome 1. Homozygosity for 129S1/SvImJ-derived alleles at Hdlq15 in conjunction with at least one C57BL/6J-derived alleleat Hdlq60 significantly increased plasma HDL levels in males and females on an atherogenic diet. Hdlq60 displays peak linkage at 124 Mb(50 cM) on chromosome X near rs6205221. This QTL did not exhibit a single-locus effect on plasma HDL concentration.

Original:  J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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