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Targeted Allele Detail
Symbol: Kmt2atm1.1Erns
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1.1, Patricia Ernst
MGI ID: MGI:3839794
Synonyms: Mll12lox, Mll1F
Gene: Kmt2a  Location: Chr9:44803355-44881296 bp, - strand  Genetic Position: Chr9, 24.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:147265
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3, and a floxed hygro cassette was inserted downstream of exon 3. Transient cre expression in ES cells was used to remove the hygro cassette. ES cells originally used to create this allele contained Mll1tm1Sjk. (J:147266)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:  79 strains or lines available
Original:  J:147265 Jude CD, et al., Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 2007 Sep 13;1(3):324-37
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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