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Smad3tm1Sche
Targeted Allele Detail
Nomenclature
Symbol: Smad3tm1Sche
Name: SMAD family member 3; targeted mutation 1, Sheldon Chen
MGI ID: MGI:3839291
Gene: Smad3  Location: Chr9:63646767-63757994 bp, - strand  Genetic Position: Chr9, 34.22 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145114
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney extracts. (J:145114)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad3 Mutation:  2 strains or lines available
References
Original:  J:145114 Wang A, et al., Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1657-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory