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Atf6tm1Kamo
Targeted Allele Detail
Nomenclature
Symbol: Atf6tm1Kamo
Name: activating transcription factor 6; targeted mutation 1, Kazutoshi Mori
MGI ID: MGI:3839240
Synonyms: ATFalpha-
Gene: Atf6  Location: Chr1:170704674-170867771 bp, - strand  Genetic Position: Chr1, 76.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145116
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 8 and 9 were replaced with a floxed promoter trap containing an splice acceptor, IRES, beta-geo cassette, and polyadenylation signal. These exons code for the entire basic leucine zipper and most of the transmembrane domain. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast lysates. (J:145116)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf6 Mutation:  9 strains or lines available
References
Original:  J:145116 Yamamoto K, et al., Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell. 2007 Sep;13(3):365-76
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory