About   Help   FAQ
Tg(Gfap-cre)77.6Mvs
Transgene Detail
Nomenclature
Symbol: Tg(Gfap-cre)77.6Mvs
Name: transgene insertion 77.6, Michael V Sofroniew
MGI ID: MGI:3838840
Synonyms: mGFAP-Cre
Transgene: Tg(Gfap-cre)77.6Mvs  Location: unknown  
Transgene
origin
Strain of Origin:  (BALB/c x C57BL/6NHsd)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. Cre expression was detected in a small population of cells within the subependymal zone in the adult brain. No Cre expression or activity was detected during embryonic development or in the hippocampus. (J:94543, J:146630)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gfap     Summary of all recombinase alleles driven by Gfap.
 

Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:146630 Gregorian C, et al., Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11;29(6):1874-86
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory